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Project
Description
THE
International
Study of Unruptured
Intracranial
Aneurysms
(ISUIA)
was
designed
to
define
the
natural
history
of
UIAs;
determine
the risk
factors
associated
with the
development
and
rupture
of
UIAs;
and
assess
the
morbidity
and
mortality
associated
with
repair
of
UIAs
among
UIA
patients
with and
without
a
history
of
subarachnoid
hemorrhage
from a
separate
aneurysm.
The
primary
hypotheses
of this
study
are as
follows.
1) Among
patients
without
a
history
of SAH
with UIA,
there is
a
critical
size
above
which
there is
a
significant
risk of
subsequent
aneurysmal
rupture,
with
accompanying
neurologic
morbidity
and
mortality.
2) Among
patients
with
UIAs
and a
history
of SAH
from
another
source,
the risk
of
future
rupture
of UIA,
disability,
and
death is
greater
than in
patients
without
a
history
of SAH
and
varies
directly
with
aneurysmal
size.
3) The
risk of
death
and
significant
disability
from
surgery
to
isolate
UIAs
from the
intracranial
circulation
varies
according
to the
size and
the
location
of the
aneurysm,
history
of SAH
from
another
source,
and
confounding
variables
such as
age and
co-morbid
conditions.
Organizational
Components
Mayo
Clinic
Coordinating
Center
University
of Iowa
Statistical
and Data
Management
Center
Investigator/Study
Center
List
ISUIA
Papers
and
Presentations
1. The International Study of Unruptured Intracranial Aneurysms: Methodology
Methods
Paper PDF file
(requires
Adobe
Acrobat
Reader)
Figure
1 (JPG
image)
2.
Unruptured
Intracranial
Aneurysms:
Risk of
Rupture
and
Surgical
Intervention
NEJM,
Dec 10,
1998
3.
Unruptured
Intracranial
Aneurysms:
Natural
History,
Clinical
Outcome,
and
Risks of
Surgical
and
Endovascular
Treatment
The
Lancet,
July 12,
2003
Other Publications and Presentations
Publication Listing
(requires
Adobe
Acrobat
Reader)
Related
Links
NINDS
Cerebral
Aneurysm
Information
Page
Brain &
Cerebral
Aneurysms
(Aneurism)
::
Wake
Forest
Neurosurgery
Mayo
Clinic:
Cerebral
Aneurysms
-
Information
and
Treatment
Cerebral
Brain
Aneurysms
American
Stroke
Association
Brain
Aneurysm
Links
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